CD4+ and CD8+ cell populations in HIV-positive women with cervical squamous intra-epithelial lesions and squamous cell carcinoma

IntroductionThis study aimed to analyse cervical lymphocytic populations in HIV+ and HIV− patients correlate different lesions with HIV viral load presence of high-risk HPV types.Material methodsA total 132 histological specimens from 40 72 were evaluated for CD4+ CD8+ T cell distribution, types, peripheral blood CD4+/CD8+ ratio.ResultsHigh-grade squamous intraepithelial (HSIL) carcinoma (SCC) had lower scores compared patients. In all lesion groups, presented higher epithelial stromal scores. was more often detectable SCC than those low-grade (LSIL) (p = 0.0409). HSIL circulating counts 0.0434) ratio 0.0378) LSIL High-risk types other 16 18/45 prevalent the group.DiscussionThese results support an imbalance between lymphocytes SIL SCC, increased infiltrate density severity, even immune system recovery under cART.